Gene Weaver Website and Tools

GeneWeaver combines cross-species data and gene entity integration, scalable hierarchical analysis of user data with a community-built and curated data archive of gene sets and gene networks, and tools for data driven comparison of user-defined biological, behavioral and disease concepts. Gene Weaver allows users to integrate gene sets across species, tissue and experimental platform. It differs from conventional gene set over-representation analysis tools in that it allows users to evaluate intersections among all combinations of a collection of gene sets, including, but not limited to annotations to controlled vocabularies. There are numerous applications of this approach. Sets can be stored, shared and compared privately, among user defined groups of investigators, and across all users.

Helpful Links:

Search Gene Weaver for any gene symbols, microarray probesets, gene set description, publication information, ontology annotation, etc.

    Submit for Curation
    Would you like to see a study added to GeneWeaver's public database? Registered users can share gene sets using the Upload GeneSet form under the Manage GeneSets menu.

    Submit experimental results for curation here.
    News and Notes
    • 2015: GeneWeaver user publication in press:
      Patrick Mulholland and colleagues used GeneWeaver to characterize the role of potassium channel encoding genes in alcohol and drug addiction. KCNN genes that encode small-conductance Ca2+-activated K+ channels influence alcohol and drug addiction by Audrey Padula, William Griffin III, Marcelo Lopez, Sudarat Nimitvilai, Natalie McGuier, Elissa Chesler, Michael Miles, Robert Williams, Patrick Randall, John Woodward, Howard Becker, and Patrick Mulholland. Neuropsychopharmacology, in press.
    • 2014: Recent GeneWeaver user publication:
      Dever et al. used GeneWeaver to perform a multi-tissue comparison of HIV encephalitis related gene expression in their paper Differential expression of the alternatively spliced Oprm1 isoform mu-opiod receptor-1K in HIV-infected individuals. AIDS, 2014, 28(1):19-30.
    • 2014: GeneWeaver Validation Study:
      GeneWeaver enabled the discovery of mouse polymorphism that influences epigenetic regulation of Ap3m2 and with effects on alcohol preference and withdrawal phenotypes. Read more.
    • 2014: Using GeneWeaver in other systems:
      Grubb SC, Bult CJ, Bogue MA (2014) Mouse Phenome Database. Nucleic Acids Research 42:D825-D834.